It’s not a good idea to get married without first having a genotyping test done on the attractive man or woman you’re considering. If you did this, you may prevent yourself from living a miserable and unpleasant life. The genotype of an organism is its complete set of genes, and this definition captures the essence of the concept. The four most prevalent genotypes are AA, AS, AC, and SS.
The importance of a genotype test before.
All engaged couples should get their genotypes checked before the big day to make sure none of them is at risk of developing sickle cell disease. Because it is a recessive genetic trait, Africa has the highest prevalence of sickle cell disease even though it affects a substantial percentage of the global population. A person’s motivation to take action should be sufficiently fueled by the fear of having a child diagnosed with sickle cell disease.
What happens when you say “I do” without a genotype test?
Sickle cell disease is more common in offspring of couples who have not taken this genotype test before getting married. The results are almost always heartbreak and regret for everyone involved.
Read the following table with care:
AA + AA = AA, AA, AA, AA (Excellent)
AA + AS = AA, AS, AA, AS, (Good)
AA + SS = AS, AS, AS, AS, (Fair)
AA + AC = AA, AA, AA, AC. (Good)
AS + AS = AA, AS, AS, SS, (Very Bad)
AS + SS = AS, SS, SS, SS, (Very Bad)
AS + AC = AA, AC, AS,SS. (Bad; Advice needed)
SS + SS = SS, SS, SS, SS, (Very Bad)
AC + SS = AS, AS, SS, SS, (Very Bad)
AC + AC = AA, AC, AC, SS. ( Bad; Advice needed)
Risk involved in getting married without a genotype test.
Getting married without first undergoing a genetic or genotype test can be risky.
1. The disease known as sickle cell anemia.
An AS couple has a 25% probability of having a child with sickle cell genotype. The general public is unaware of this. According to these data, the risk of having a child with sickle cell disease does not go down with each consecutive pregnancy. Approximately one in four pregnancies will result in a kid with this disorder.
Sickle cell disease is a lifelong disorder that has far-reaching consequences. The severity of the illness might vary greatly. As a result of advances in diagnosis and treatment, the life expectancy of people with SCD has increased to between 40 and 60 years in high-income countries. In countries where the median income is just $23,000, a child born with SCD has a life expectancy of only 23 years.
Patients with SCD might expect to spend their life in and out of the hospital owing to the unpredictability and intense discomfort they encounter. Joints, bones, eyes, liver, heart, and kidneys are just some of the body parts that may be negatively impacted by SCD.
What is the most compatible Genotype for marriage?
A marriage between two people with the same genotype (AA) is the most successful. It’s ideal for two AAs to find one other and start a family. That way, you can have children without worrying about whether or not their genes would be compatible. It’s a fact that you two will start a family together after the wedding.
The Bottom Line.
•Genetic compatibility is an important factor in building and maintaining a successful marriage. To play it safe, get tested for your ancestry and compatibility with your partner before tying the knot. But if you and your partner love and cherish each other deeply, there is nothing wrong with choosing not to start a family.