Sertraline: Side Effects & Interactions

Side effects of sertraline

side effects to sertraline
sertraline antidepressant capsules

Sertraline Side effects to sertraline however, many people take sertraline with no or minimal adverse effects.

As your body adjusts to sertraline, the symptoms of its most common adverse effects should lessen.

Sertraline may make anxiety worse for some people during the first few weeks of treatment for panic episodes. This typically fades within a few weeks, but if it persists, talk to your doctor. Your symptoms could be alleviated by taking a smaller dose.

Common side effects

side effects to sertraline
Medical vial with Sertraline pills. Medical pills in orange Plastic Prescription

More than 1 in 100 people who use sertraline will experience these typical adverse effects. The good news is that you can take action to alleviate their effects:


I’m starting to feel ill (nausea)


The state of being sleepless

Tired to the point of sleepiness


Chapped lips

A feeling of vertigo has set in

Weak or exhausted.

Keep taking the medication, but consult your doctor or pharmacist if any unwanted effects persist or become intolerable, even after using the suggested coping mechanisms.

Serious side effects

Serious side effects from sertraline are uncommon (affecting less than 1 in 100 people), but they can occur.

To see a doctor, please do so if you experience:


. Changes in your menstrual cycle, such as increased or decreased flow or bleeding in between periods

. Involuntary gaining or losing of weight

. You feel like you can’t sit or stand still; you’re overcome with euphoria (extreme joy), eagerness, or enthusiasm;

. yellowing of the skin or the whites of the eyes (less evident on people of color) is a warning sign of liver disease.

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. Bleeding from the nose, mouth, or genitalia

.It’s possible that internal bleeding is occurring if you’re passing bloody or dark-colored stool, or if you’re puking up what looks like blood.

. Your gums are bleeding, you have random or worsening bruising, etc.

Long-term side effects

side effects to sertraline
Sertraline molecule. It is antidepressant, used to treat depressive disorder, social anxiety disorder, other psychiatric conditions.. Structural chemical formula, molecule model. Vector illustration

Some people may experience undesirable sexual side effects, such as an inability to get or maintain an erection or a diminished desire to engage in sexual activity. Sometimes these symptoms persist even when the medication is no longer taken. If you’re worried, make an appointment with your doctor.

One study found that people who took sertraline for longer than a year had a marginally higher chance of developing diabetes. There will be periodic checks to make sure you’re doing this.

Other side effects

side effects to sertraline
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The negative consequences of sertraline do not end here. The information sheet included with your medication will provide a complete rundown.


Interactions between drugs can alter their effects or boost your risk of adverse reactions. Some drug interactions may not be listed here. Always inform your doctor and pharmacist of anything you take, whether it’s a prescription pill, over-the-counter medication, or a herbal supplement. Never adjust the dose or stop taking a medication without first seeing your doctor.

Drugs that increase the risk of bleeding or bruising (such as aspirin, ibuprofen, naproxen, and “blood thinners” like warfarin and dabigatran) may interact with pimozide.

These drugs may have a deadly drug interaction if used together with an MAO inhibitor. You shouldn’t combine this drug with any monoamine oxidase inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine). In addition, most monoamine oxidase inhibitors (MAOIs) should be avoided two weeks before and after treatment with this drug. When to take this medication and for how long should be determined by your doctor.

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Combining multiple serotonin-increasing medications raises the danger of serotonin syndrome/toxicity. Drugs like MDMA/”ecstasy,” St. John’s wort, and other antidepressants (such as other SSRIs like fluoxetine/paroxetine and SNRIs like duloxetine/venlafaxine), as well as tryptophan, are all examples. When starting or increasing the dosage of these medications, the risk of serotonin syndrome/toxicity may increase.

Do not take this medication if you have recently used alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, or opioid pain or cough relievers without first consulting your doctor or pharmacist (such as codeine, hydrocodone).

It is important to read labels carefully since some medications (such as allergy or cough and cold remedies) contain components that can impair your ability to drive safely. Inquire with your pharmacist about the secure use of these items.

This drug should not be taken with aspirin due to the increased risk of bleeding. Except until otherwise instructed by your doctor, you should keep taking low-dose aspirin (about 81-162 milligrams daily) for the prevention of heart attack or stroke.

Some medical and laboratory tests (such as a brain scan for Parkinson’s disease) could be impacted by this medicine, leading to inaccurate results. Do not forget to inform the lab staff and your doctors that you are on this medication.


If you suspect an overdose and the victim is experiencing life-threatening symptoms like loss of consciousness or difficulty breathing, dial 911 immediately. When in doubt, contact a poison control center. To reach a poison control center in the United States, dial 1-800-222-1222. There is a provincial poison control center in Canada that can be contacted via phone. Extreme dizziness and fainting are possible overdose symptoms.

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It is imperative that you keep this drug to yourself.

See your doctor or therapist regularly.

Missed Dose

Take the missed dose as soon as you realize you forgot. It is best to forgo the missed dose if it is getting close to the time of the next scheduled dose. Don’t forget to take your next dose when it’s due. Don’t try to make up for lost time by taking twice as much.


Keep out of the fridge and out of the fridge. Don’t keep anything in there. Keep any drugs out of the reach of kids and pets.

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